Given a network motif structure representing a specific biological function in one cell type or species, this approach utilized a comparative modeling strategy to connect it with other network motifs which are evolutionarily related to each other.
Even so, the enrichment of a biological function in one condition merely suggests greater relative abundance of transcripts for the encoded proteins associated with the biological function and it does not necessary mean the absence of this biological function operating in the condition that is not enriched.
IPA analysis also indicated that Lipid Metabolism was one of the main biological functions in the comparative dataset.
Biological networks constructed by bioinformatic methods can help 'put the function in genomics, and allow researchers to understand how biomolecules interact with one another at the system level to perform specific biological functions in living plant cells.
The p73 transcription factor is one of the members of the p53 family of tumor suppressors with unique biological functions in processes like neurogenesis, embryonic development and differentiation.
In this application, the G × E analysis could be extended by considering multiple GRPS and hence multiple genetic and G × E terms based on biological function, e.g., one based on SNPs in calcium ion channel genes (e.g., Purcell et al. 2014) and one based on the remaining SNPs.
In addition, we explored its biological function in vitro.
Additionally, gene duplication is an important source of new biological functions because mutations in one of the copies can affect protein structure without being deleterious, whereas the other copy can retain functionality [ 50, 51].
Since piRNA genes have already been shown to have signatures of faster evolution, we attempted to avoid polluting this control set of faster evolving genes with other unknown piRNA genes by requiring genes in the control set to have a biological function not one involved in an RNA mediated process, as indicated in the Flybase gene summary http://www.flybase.org.org
Interacting proteins with high confidence scores in such a PPI network are more likely to share similar biological functions than noninteractive ones [ 23– 25].
