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STAT3 has many biological functions in normal cells and, like other oncogenes, is insufficient on its own to cause cancer.
MiRNAs regulate various biological functions in normal cells such as growth and differentiation, and they are increasingly recognized as playing critical roles in cancer development and progression.
One of these factors is the pleiotropic cytokine IL-6, a cytokine mediating diverse biological functions in normal tissues and of particular importance in the promotion of myeloma cell expansion and survival.
WNT-1 induced secreted protein 3 (WisP3) is a member of the CCN family of proteins, which have important biological functions in normal physiology as well as in carcinogenesis [ 6- 8].
It also remains to investigate why CD133 is usually present on apical membrane of normal bile ducts or other gland lumen, why it is transferred from apical membrane to cytoplasm in cancer cells and what its biological functions in normal bile duct epithelium and cholangiocacinoma are.
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The pro-oncogenic role of Notch activation in GBM is thought to reflect its biological function in normal CNS development.
With 47% amino acid similarity to DPP4, it is possible that DPP10, apart from associating with Kv4 channel complex through its single transmembrane domain [ 55], may also interact with other proteins and ligands via either its extracellular β-propeller domain or its intracellular domain and these interactions may control its biological function in normal and pathological conditions.
For example, whether an entity counts as a heart depends (roughly) upon whether its biological function in its normal environment is to pump blood.
A normal biological function in vivo usually involves a series of phosphorylation processes [2].
In spite of the importance of myocilin in inherited glaucoma pathogenesis, little is known about its normal biological function in the TEM, especially the OLF (myoc-OLF) domain.
Therefore, recombination between syntenic regions 7 and 11 in normal radish can lead to loss of biological function in mitochondria.
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biological pathways in normal
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