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In this study, the biological functionality of a bioink composed of nanofibrillated cellulose and alginate (NFC-A) is extensively evaluated for auricular cartilage TE. 3D bioprinted auricular constructs laden with human nasal chondrocytes (hNC) are cultured for up to 28 days and the redifferentiation capacity of hNCs in NFC-A is studied on gene expression as well as on protein levels.
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Lipids play a key role on the biological functionality of membranes, by providing a permeable barrier and by maintaining its liquid crystalline state [ 95].
A subnet allows the study of the interplay between pathways and reactions in a broader context, while still focussing attention on a limited biological functionality of interest.
A combination of high-throughput material formulation and microarray techniques were synergistically applied for the efficient analysis of the biological functionality of 135 binary polymer blends.
This method allowed achieving a dispersed-isolated state of the solid phase and the formation of colloid systems with satisfactory aggregative stability associated with biological functionality of metal colloidal solutions.
Moreover, immunohistochemistry results showed that cells seeded on the scaffold maintained their endothelial phenotype, demonstrating the biological functionality of the microfabricated GelMA scaffolds.
The main parameters affecting the scaffold performance concern morphology and architecture (e.g., pore shape, size, distribution, and interconnectivity), structural properties, and surface chemistry, the latter affecting cells adhesion and growth, and therefore the biological functionality of the graft.
The biological functionality of the protein-NP conjugate depends on the protein's ability to interact with target molecules, which is affected by NP characteristics such as size, curvature, aspect ratio, morphology, crystal structure, and surface chemistry.
The retention of the biological functionality of such DNA probe molecules, immobilized in the solid state with various spatial resolutions (down to submicron features), was subsequently assessed by probing their specific reactivity toward a solution containing a complementary target sequence (see "Experimental" for details).
The biological functionality of Eg5-GFP was confirmed by its ability to rescue spindle formation in Eg5 depleted Xenopus egg extract (Fig. 4A), as shown previously [30], [31].
It is widely accepted that most of the biological functionality of the cell arises from complex interactions between their molecular components that define operational interacting entities or modules [8].
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