The biological function of miR-96 in protection against apoptosis and cell survival, as related to FOXO3a function, is currently under investigation in our laboratory.
We have examined the biological function of four validated prognostic genes for MPM and obtained evidence that three of them are involved in some way with protecting the tumor cell from apoptosis.
Given the increased evidence that ER stress-induced apoptosis is one of the mechanisms of β-cell loss in T2D (Eizirik et al, 2008), it was of interest to further assess the biological functions of two putative ER stress-related genes that we found to be hypomethylated in T2D islets, namely NIBAN and CHAC1.
Useful insights into the development of pharmacological approaches are emerging from a growing understanding of the biological functions of three known CCM genes: KRIT1, CCM2 and PDCD10.
Predicting the role of orthologues separated over a long span of time has been a difficult proposition, especially in the context of the multidomain proteins with frequent insertions/deletions. Accordingly, the biological functions of six domains of HOXC11 protein such as DUF3528, Homeodomain, COG, PHA, KGD and PRK are still unclear.
To study the biological function of OsPYLs, two OsPYL genes (OsPYL3 and OsPYL9) were overexpressed in rice.
An understanding of the biological function of these two protein markers further clarifies their contribution to prognosis.
In order to study the biological function of the two plant MYST proteins, we performed a genetic analysis using Arabidopsis mutants.
However, ATTGG + CCAAT and AGATA + TATCT are underrepresented only in a half portion of the mouse genome, indicating that the biological function of these two pentanucleotides may differ from that for human.
Our revision of the gene structure of Pf332 has paved the way to dissect the biological function of Pf332, one of the largest proteins found in P. falciparum parasites.
