Sentence examples for biological function of specific from inspiring English sources
Because these predictions are prone to false positives and false negatives, there is an ever present need to provide material support to these assertions to firmly establish the biological function of specific miRNAs in both normal and pathophysiological contexts.
The BXD reference panel allowed us to establish genetic regulation and characterize biological function of specific miRNAs.
Finally, many signalling pathways, including activation of p53 [ 32], involve post-translational modifications such as protein phosphorylations, deacetylations, and so on, meaning that information relevant to changes in biological function of specific proteins is not reflected in altered mRNA expression.
Given that class I KDACs can deacetylate histones, KDAC-recruiting factors, components of the co-repressor complexes and even KATs, it is challenging to dissect the individual contributions of histone and non-histone substrates to the biological function of specific KDACs (see below).
Furthermore, mouse models make it possible to control confounding environmental factors and to investigate the most informative phenotypes of renal aging by analyzing the histological changes in detail, and ultimately they provide a platform for studying the biological function of specific candidate genes via experimental intervention studies.
Conversely, human diseases provide fascinating windows into biological functions of specific molecules, the ability of biological systems to compensate for missing or toxic molecules, and the spiral of pathogenic mechanisms that lead to cell, tissue and organ malfunction.
Transcriptional regulation of MAPK cascade components thus appears to provide an important level of control in plants, suggesting that systematic analysis of their transcriptional patterning in a given plant species should provide insight into potential biological functions of specific classes of these signaling components.
Insight into mechanisms underlying G × E might help us form theory-based hypotheses, for example, by using assumptions on the biological functions of specific genetic markers in choosing which marker is likely to interact with a specific environment in predicting a specific outcome.
Cells take up Fe bound to Tf using Tf receptors (TfR); thus, the biological function of the specific receptors is to bind Tf on the cell surface and ingest it.
However, in many patients, neutralizing antibodies cannot be detected, and therefore the biological function of filovirus-specific non-neutralizing antibodies remains unclear.
As for specific mutations that may affect the biological function of such gene, coincidentally, specific triple Y156F/S101A/S174A-RhoGDI mutation has been confirmed to be related to the progression of pancreatic cancer [ 58].
