Recently, light has been used as a trigger to control the biological function of small molecules, oligonucleotides, and proteins involved as parts in gene circuits.
Although the biological function of these molecules has not been severely affected by QD conjugation in most reports, advances in conjugation strategy/chemistry are still needed in the future to provide a robust platform for QD functionalization.
This is a form of chemical recoding that changes specific amino acid residues and alters the biological function of translated molecules, which is most clearly demonstrated by an alteration in channel properties including the Ca2+ permeability of glutamate receptors (GluRs) [15].
Furthermore there is growing evidence of a connection between regions of unpaired nucleotides and the concrete biological function of RNA molecules.
Thus, the computed ensemble models highlighted a hitherto unnoticed phenomenon of molten cores in folded proteins, which are likely relevant for the biological function of these molecules.
This is consistent with the conserved biological function of the molecules and allows us to conclude that it is highly unlikely that the CARDs of human CARD9 and human NOD2 would interact either.
However, some MeSH annotations are too general (such as solvents, carcinogens, inhibitors, and so on) to describe a specific biological function of the molecule.
Although co-crystal structure of BoNT/A light chain (LC) reveals some unique features of the biological function of this molecule, structural characteristics in solution reveal its dynamic features, not available through the published crystal structures.
Modifier: this refers to any drug or drug-like compound or laboratory method that can modulate the biological function of a molecule of interest so to interfere with the efficacy of a therapeutic agent.
These findings suggest that this method is useful for intracellular delivery of antibody and for analysis of biological function of sub-cellular molecules in living cells.
