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ONTO/express (http://vortex.cs.wayne.edu/ontoexpress/) was used to define biological function of genes from each comparison, and Gene Set Enrichment Analysis (GSEA, http://www.broad.mit.edu/gsea/) [48] to examine how expression profiles from the filtered lists fit into known and archived biological pathways.
The fourth column indicates if the genes were also classified as synaptic by the 3 algorithms with a probability above 0.9 One of the main goals of functional genomics is to make predictions on the biological function of genes from the information stored in large-scale datasets, maximizing the utility of available information and making predictions of function with verifiable performance [ 11].
Knowledge of the history and biological function of genes helps explain why scientists are almost unanimous in their endorsement of the safety of GMOs.
Pathway-based analysis helps to further understand the biological function of genes.
Gramene (www.gramene.org) was used to find the annotation and biological function of genes.
The relationships between genes and thyroid function, ionizing radiation, and thyroid cancer and biological function of genes have been assessed using literature reports.
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Thus, the definition of a precise intermediate phenotype that is closely linked to the biological function of gene expression is imperative.
Motivation: Several functional gene annotation databases have been developed in the recent years, and are widely used to infer the biological function of gene sets, by scrutinizing the attributes that appear over- and underrepresented.
Pathway-based analysis does not only elucidate the biological functions of genes but also further identifies significantly enriched metabolic pathways or signal transduction pathways in DEGs against the whole genome background (Zhang et al. 2012; Wymelenberg et al. 2010).
The biological functions of genes that reproducibly displayed differential expression in all B. napus lineages were not over or under-represented by any specific functional class of gene.
The application of microarray technology has been stimulating methodological development on data analysis that help biologists to gain more insights into biological functions of genes.
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biological characterization of genes
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