All organisms, including eukaryotes and prokaryotes, share a common heat shock response mechanism, which involves a number of reactions, including new protein synthesis, folding, intracellular targeting, specific biological functions, and protein degradations.
Lastly, future studies should also attach some importance to circRNA-involved regulatory network, which would help us comprehensively understand the formation, biological and physiological function, and degradation of circRNAs.
However, whether Sl3-MMP exerts its biological function through degradation of plant ECM components needs to be further investigated.
The stress response enzyme heme oxygenase 1 (HO-1) is expressed ubiquitous in the body tissue and mediates, besides its major biological function of heme degradation, a variety of anti-inflammatory effects.
The decomposition of the entire network into metabolic pathways is generally done according to biological functions: molecule degradation (catabolism), molecule synthesis (anabolism) or energy transfer [ 21].
Laccase enzymes are widespread among plants, fungi and bacteria, and have various biological functions, such as degradation of complex polymers (lignin, humic acid), lignification, detoxification, pathogenicity, morphogenesis, sporulation, polymerization of melanin and spore coat resistance (Strong & Claus 2011).
Many plant β-galactosidases (Bgals) have been well characterized and their deduced biological functions mainly involve degradation of structural pectins, xyloglucans or arabinogalactoproteins in plant cell walls.
While all other proteins related to protein synthesis, folding and degradations showed enlistment under categories of GO (biological function, molecular function and cellular component) (Additional files 9 and 10).
Our finding that DHA simultaneously induced UPS activation and E6/E7 degradation highlights a novel biological function of DHA, and reveals one important mechanism by which DHA provokes the death of HPV-associated cancer cells.
This situation happens for clusters which are mainly composed of genes related with the biological function of protein synthesis and protein degradation as indicated in Figure 12.
