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These endogenous cell death 'back up' mechanisms, in co-operation with an enhanced ability to recruit caspase-8 to the DISC, therefore provide a biological framework that can be therapeutically explored by these combined treatment paradigms.
Pathways are uniform biological framework that can be used for functional modelling of microbial metabolisms.
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The IUPS Physiome Project aims to facilitate the understanding of physiological function in healthy and diseased mammalian tissues by developing a multi-scale modeling framework that can link biological structure and function across all spatial scales.
This synthesis between biological disciplines allows us to develop a modelling framework that can help to answer some important strategic questions.
Toward this end, we present the 'tagtog' system, a web-based annotation framework that can be used to mark up biological entities (such as genes) and concepts (such as Gene Ontology terms) in full-text articles.
The use of mutual information provides a universal framework that can be applied to any type of biological data, be it discrete or quantitative, and the algorithm can be applied to proteome-scale data from any organism, including humans.
While it is the framework that can provide general model independent bounds on information processing in biological systems, it is also one of the most elusive, misunderstood and abused conceptual theories.
Work focused on P. falciparum show how layers of biological detail can be added to the trade-off model in order to provide a framework that can predict more quantitative outcomes (Alizon and van Baalen 2005) and test hypotheses about virulence evolution in the field (Mackinnon and Marsh 2010).
Similarly the 1,238 RMP specific genes are likely to provide the biological framework that separates the rodent from primate malaria.
An ANOVA framework, however, also allows for a more complicated experimental model that can incorporate normalization and multiple biological conditions.
Our approach to image analysis may be applicable to a variety of biological objects that can be represented as a framework of connected lines.
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