Sentence examples for biological evaluation of two from inspiring English sources

The design, synthesis, as well as biochemical and biological evaluation of two novel achiral analogs of duocarmycin SA (DUMSA), 1 and 2, are described.

Results report the design, ADME-Tox prediction, synthesis, solubility determination and in vitro biological evaluation of two 1,4-dihydropyridines (DHPs).

The synthesis, structural characterization and in vitro biological evaluation of two 2-(4′-aminophenyl benzothiazole based ligands and their corresponding Pd(II) and Pt(II) complexes is reported.

The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein.

In the current study, we report the design, synthesis and biological evaluation of two novel series of 2-amino cyanopyridine series (5a-g) and 2-oxocyanopyridine series (6a-g) targeting Pim-1 kinase.

Investigation of whether the improved biological activities are due to steric and electronic factors of the trifluoromethyl group led to the design, synthesis and biological evaluation of two analogous alkyl sulfone molecules, methyl sulfone (AU-16-ene-25-SO2 CH3) AU-16-ene-25-SO2 CH3e (AU-16-ene-25-SO2 CH3r). AU-16-ene-25-SO2 CH3

This paper describes the synthesis and biological evaluation of nine epoxomicin-derived sugar amino acid containing peptide epoxyketones.

Herein we present the design, synthesis, and biological evaluation of three different series of novel sulfonamides (3a-f, 6a-f and 9a-f) incorporating substituted indolin-2-one moieties (as tails) linked to benzenesulfonamide (as zinc anchoring moieties) through aminoethyl or (4-oxothiazolidin-2-ylidene)aminoethyl linkers.

In this study, we described the design, the preparation, the characterization and the biological evaluation of three new series of CA-4 analogs namely styryl-N-phenyl-N′-ethylureas (SEUs), styryl-N-phenyl-N′- 2-chloroethyl)ureastyryl-N-phenyl-N′- 2-chloroethyllidin-2-onestyryl-N-phenyl-N′- 2-chloroethyla), 3,5-Me (styryl-N-phenyl-N′- 2-chloroethyltituents, styryl-N-phenyl-N′- 2-chloroethyl

In this work we report synthesis, in vitro and in vivo biological evaluation of five new hybrid EM2/DAMGO analogues, with the aim to obtain compounds with high affinity at μ-opioid receptor, high activity in animal nociception tests (hot plate and tail flick) and improved enzymatic stability.

We here report the synthesis and biological evaluation of six pairs of chiral ureidopropanamido derivatives as potent and selective formyl peptide receptor-2 (FPR2) agonists that were designed starting from our lead agonist (S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl S -3- 1H-indol-3-yl -2-[3- 4-methoxyphenyl