Sentence examples for biological driver from inspiring English sources

Several genes coding for proliferation factors, a key biological driver, are targeted in these genomic profiling tests [ 12, 26, 58, 112, 113].

Users may experience addiction-related problems that complicate access to healthcare and aggravate transmission, possibly aggravated by a biological driver that may increase susceptibility to infection and progression to infectious disease.

In this study, using genome-wide profiling of breast tumours from multiple cohorts as well as validation by cell-based phenotypic assays, we identified for the first time that SPINK1 is a biological driver of aggressiveness in breast cancer.

TNF-α is a strong biological driver of the metabolic syndrome, which is characterized by abdominal obesity, hypertension, a reduced level of HDL, elevated triacylglycerols and high-fasting glucose, and constitutes an important risk factor in atherosclerosis and Type 2 diabetes [ 86].

This approach was based on two hypotheses: (i) that significant CNA of a potential seed gene should also be reflected in the expression of the corresponding mRNA; and (ii) that seed genes surrounded by genes with significantly increased expression or expression-correlation are more likely to represent biological driver functions than genes that do not affect their network neighbourhood.

Here, we investigated whether epigenetic silencing of Wnt antagonists is the biological driver for this increased Wnt activity in human tissues and how these methylation changes correlate with MSI (Microsatelite Instability) and CIMP (CpG Island Methylator Phenotype) statuses as well as known mutations in genes driving colorectal neoplasia.

Other areas of medicine, cancer in particular, have been transformed by better understanding of the biological drivers of disease.

Similarly, mineralization of organic carbon, nitrogen, and phosphorus in soil and water, the biological drivers of which are extensively studied, may also proceed photochemically.

Studies on animals with mating or migration patterns that revolve around lunar cycles could also illuminate the underlying biological drivers as well as the evolutionary benefit of having a moon-synced clock.

In particular, as the available omics data for CHO cells continue to grow, predictive models and screens will be increasingly used to unravel the biological drivers of protein production, which can be used with emerging genome editing technologies to rationally engineer cells to further control the quantity, quality and affordability of many biologic drugs.

Here, by simply defining the genes involved in energy metabolism, we were able to find co-expression patterns in white-blood cell derived samples – the biological drivers for the patterns are then open to investigation.