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Whether these apparent disparities reflect biological divergence sufficient to translate into distinct ecological regimes (or animal reservoirs) bears investigation.
Therefore, a large norm for MV is defined by a relatively small number of co-regulated groups of genes, and these groups are related to the biological divergence of patients (including the divergence of their response).
Interestingly, this analysis did not demonstrate an obvious PD-linked biological divergence between both groups, i.e., neither profile pointed to a particular or prominent gender-specific dysfunction of PD-relevant pathways.
From an evolutionary viewpoint, sequences that adopt a conformational ensemble can propagate biological divergence through multifaceted selective pressures.
We hypothesize that subtle changes in conformational flexibility can drive biological divergence among proteins that seem structurally and functionally conserved, such as orthologous proteins in closely related species.
Thus, the results presented here support the view that mutation-driven extended conformational selection is a potential mechanism for biological divergence.
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The biological divergences between the brood stages of western and eastern bees still remain unknown.
Unfortunately, these two sources of information ('rocks' and 'clocks', respectively) often yield starkly disparate estimates of the timing of major biological divergences [ 5].
And pathways such as the amino acids and other biomolecular synthesis and metabolism, polysaccharide and saccharide metabolism, insecticide resistance and detoxification, might have been subjected to strongly positive selection and play important roles in biological divergences of these two agriculturally important aphid species.
There are two complementary sources of information for dating ancient biological divergences: (1) physical historical remains (either paleontological or ichnological); and (2) molecular sequence differences among extant taxa, the analysis of which requires assumptions about the processes and rates of sequence evolution.
A series of controls for experimental and biological variance show that most of this divergence does not result from experimental noise.
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