Sentence examples for biological demonstration from inspiring English sources

We report biological demonstration of alloimmunisation without signs of rejection in four grafted patients out of 13 studied during the course of a clinical trial involving fetal neural transplantation in patients with Huntington's Disease.

Biological demonstration of alloimmunisation against the graft tissues was provided by haplotyping preserved frozen samples from the three foetuses used for grafting, with HLA-A*3 allele in the foetus grafted on the right side, HLA-A*11 in one of the two foetuses grafted in the left striatum.

While this experiment was not designed to provide a definitive biological demonstration of oxidative stress-induced gene expression, it is encouraging that this analysis has identified six genes known to be altered following oxidative stress (HMOX1, NQO1, TFRC, P21, MGST1, CCL5) and five genes clearly related to repair of DNA damage (P21, GADD45, DDB2, XPC, ATF3).

Of all three different aspects of biological significance demonstration, our results all showed improvement over the three previous works.

57 Ultimately, identifying causal genes and linking their altered expression to GWAS risk SNPs requires a plausible biological mechanism or demonstration of allele-specific expression, or both, 53 tasks which are technically challenging even when working with primary human cell types that can be sampled with relative ease, such as peripheral blood.

Biological, radiological and clinical demonstration of an ongoing rejection process was observed in a fifth transplanted patient.

The finding of a positive correlation between IL-13 levels and MDSC numbers in our study lends yet more biological plausibility to the demonstration and importance of elevated IL-13 in these diseases, given that IL-13 also appears to be pivotal for the full immunosuppressive functionality of MDSCs.

The EMA adopted biosimilar guidelines in 2006 that address the following: (1) quality issues in analytical studies (e.g., selection of a reference product, methods, product characterization, and demonstration of biological activity and purity) 17 and (2) nonclinical and clinical issues (e.g., pharmacotoxicological assessment, pharmacokinetics, pharmacodynamics, efficacy, and safety).

Importantly, the candidacy of several novel players must first be dependent on a demonstration of their biological relevance to cardiogenesis.

Figure 10 shows an example set of search results when searching for a particular biological process term in the demonstration database.

This expansion would allow for a demonstration of the biological significance of different types of stress exposure (that is, the molecular pathways affected) or for obtaining a quantitative measure of the effect of stress on mammary cells.