However, it is not clear how inhibition of one or a few genes has profound effect in biological decision-making.
Simple switches and oscillators have been shown to map to the core processes of biological decision-making, implemented by two- or three-gene network motifs and characterized by their behaviour around the systems' fixed points [ 17- 22].
Signal duration (e.g. the time over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proliferation, and developmental lineage commitments.
We included terms such as bioterrorism, biological warfare, decision support system, detection, diagnosis, radiology information systems, and public health.
In order to find the substructures most associated with biological activity, decision trees (Rusinko et al., 1999, 2002; van Rhee, 2003; Young and Hawkins, 1995) were used to partition compounds in the Chembridge Diverse Set E library based on the presence or absence of highly discriminating substructures chosen from the set of 4860 substructures.
Foremost, it is unclear if these biological and decision-making deficits represent premorbid conditions, the sequelae of chronic cocaine use, or perhaps even polysubstance abuse, as most cocaine-dependent subjects had also abused at least one other drug during their lifetime.
The result is valuable in understanding the behavioral and biological underpinnings during decision making and gambling process.
Biological organisms perform decision making based on classification of external environmental cues at all levels from intracellular (e.g., ref (13)) to organismal and even population-wide.
