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This indicates that our proposed method can identify more biologically relevant genes than an unweighted FDR method, which ignores existing biological data and knowledge.
Biology-specific data, knowledge, and software resources are drawn from the BioBike environment [2], an integrated biological data and knowledge repository and biology-specific programming environment.
In modern time, manual curation of databases is made to ensure transmission of biological data and knowledge.
We chose the model plant Arabidopsis Thaliana for this work given its rich availability of biological data and knowledge.
(Researchers dealing with large-scale data may want to consider the 'Semantic Web', which is becoming a new standard for representation of biological data and knowledge.
We have developed a novel IMP-WFDR method that derives weights from a state-of-the-art data integration algorithm and incorporates them in WFDR to more effectively account for multiple test given the context of available biological data and knowledge.
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Our method intertwines stringency level settings, biological data and a knowledge database to highlight molecular interactions using networks and pathways.
The prediction capability of SVM can be further enhanced with increasing availability of biological data and more extensive knowledge about sequence, structure, transcription, post-transcriptional processing features that define the functional profiles of proteins and peptides.
iAB-RBC-283 is a proteomic based metabolic reconstruction and a biochemical knowledge-base, a functional integration of high-throughput biological data and existing experimentally verified biochemical erythrocyte knowledge that can be queried through simulations and calculations.
As the quantity of this information increases, easy access to multiple layers of biological data and information enables improved extraction of knowledge, thus increasing the value to the user.
Discovering new biological knowledge from high-throughput biological data and assigning biological functions to all the proteins encoded by the genome is, however, challenging and allowing systems level investigations of microbial cell factory.
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