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After finding significant loci of differential regulation and cell-type specificity, the users can intersect the loci with other biological data and functional annotations to derive hypotheses.
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The corresponding surrounding signaling networks are also integrated, expanded, or modified as more functional biological data and sequencing data become available.
Second, although our study suggested that rs3748067 and rs8193036 variations of IL-17A gene were associated with the risk of CWP, more biological background data and functional studies are needed to explain the results.
This is apparent both when using a standard train-test approach and when analyzing biological data for functional assignments.
As the output of biological assays increase in resolution and volume, the body of specialized biological data, such as functional annotations of gene and protein sequences, enables extraction of higher-level knowledge needed for practical application in bioinformatics.
FF collected the datasets, carried out expression data and functional annotation analyses and participated in the biological interpretation of results.
There are many biological data types - the most common include sequence data (nucleotide or protein), molecular structures, expression data, and functional annotations.
Her research interests include protein family classification and functional annotation, biological data integration, and literature mining.
To understand the role of these variants in susceptibility, we need to derive mechanistic insight by integration of genetic results with other biological data types and also with careful functional studies.
Enriching basic biological data with higher-level functional annotations and facilitating specialized analyses in organized workflows enables extraction of higher-level knowledge.
L.C. and M.P. contributed to biological data collection and analysis.
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