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Using our approach, we showed that the quality, as measured by the biological cohesion of DEGs, can vary greatly between microarray experiments.
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To help users assess each PAG's biological relevance, we developed a cohesion measure called Cohesion Coefficient (CoCo), which is capable of disambiguating between biologically significant PAGs and random PAGs with an area-under-curve performance of 0.98.
We also discuss the biological importance of robust pericentromeric cohesion and early centromere replication, as well as the mechanisms orchestrating these two functions at the microtubule attachment site.
To evaluate the biological relevance of PAGs, we developed three PAG cohesion measures, i.e. Cohesion by Interaction enrichment (CoI), Cohesion by Triangle enrichment (CoT) and CoCo.
Extracellular proteins play a key role in generating and maintaining cohesion and adhesion in biological tissues.
One of the missions of FIS is organizing a sound body of new thinking about the informational cohesion of the physical, biological, and social realms.
Marijuán says one of the missions of FIS is "organizing a sound body of new thinking about the informational cohesion of the physical, biological and social realms" of science.
However, the biological process giving rise and maintaining cohesion of these groups is what matters in a species concept.
Here, we have extended this functional cohesion method to determine the biological significance of larger gene sets, which are typically found in microarray studies.
Sister chromatid cohesion is an evolutionarily conserved biological process that ensures the faithful segregation of genomic DNA from mother to daughter cells.
There can be many biological or technological reasons for the lack of cohesion in any microarray dataset.
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