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An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose.
New approach to biological circuit design enables scientists to track cell histories.
The synthetic biological circuit at the core of the technology uses a regulatory DNA sequence that tightly controls the synthesis of the principle fiber-assembling protein.
One approach to adjust the LN model to the biological circuit structure is to use multiple parallel filters that capture ON and OFF bipolar inputs.
"Taken together, these tools enable a predictable biological circuit design cycle that dramatically increases the efficiency, safety and sophistication of genetic engineering," Arkin says.
The performance of both alternatives is then checked in the design of a well-known biological circuit: a genetic incoherent feed-forward loop showing adaptive behavior.
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Hart, Y. & Alon, U. The utility of paradoxical components in biological circuits.
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