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In this report we describe the synthesis and biological characterization of two series of sirtuins' inhibitors (SIRTi), designed as simplification products of the previously reported SIRT1-selective inhibitor MC2141 (4).
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In this study, we report the synthesis and biological characterization of nine peptides that replace only the d-Arg residue of the FM 19 sequence, investigating ways to add conformational restriction, modification of the basic moiety at the end of the side chain, and removal of the charge from the N-terminus.
Transient expression and biological characterization of selected gp160 constructs identified six clones to encode full length and functional envelope glycoproteins.
The biological characterization of the cellulose matrix (control scaffold) and the three developed mineralized cellulose samples was conducted with MG63 human osteoblastic cells, for a period of 7 days.
Chemical and biological characterization of PHY906 demonstrated that a large number of bioactive substances are present in the four herbal preparations.
Virus Discovery - molecular and biological characterization of novel viruses.
Alderson, M.R. et al. Molecular and biological characterization of human 4-1BB and its ligand.
I. Isolation and physico-chemical and biological characterization of SF-1293 substances.
Wang, Y. S. et al. Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications.
Biological characterization of BACE inhibitors 6 8 is described.
Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer.
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