Sentence examples for biological activity using a from inspiring English sources
Our in-depth, large-scale mapping of novel glycosylation sites represents a crucial step toward systematically revealing the functionality of N-glycosylated RJ proteins, and is potentially useful for producing a protein with desirable pharmacokinetic and biological activity using a genetic engineering approach.
For this purpose we investigated the biological activity using a broad variety of cancer cell lines in vitro and, importantly, the well established C3 mouse model in vivo.
Each Wnt3a mutant was first tested for its biological activity using a Wnt reporter assay.
In order to appreciate whether anti-ricin scFv could function as an effective therapeutic against ricin intoxication, 43RCA was tested for its ability to neutralize ricin biological activity using a cell-free translation assay.
The ultimate measurement of an immunotherapeutic drug is an objective clinical response, but other measurements of its biological activity using a suitable quantitative biological assay that is linked to the relevant biological properties are highly appropriate during the developmental phase.
Because this mutation did not impair caspase-8 cleaved recombinant BID (cBID) integration in purified mouse liver mitochondria (MLM) (Wei et al., 2000; Figure S1D), we could measure its biological activity using an established quantitative, specific cytochrome c release ELISA (Scorrano et al., 2002).
Based on a piperazine alkyl derivative that induced apoptosis via up-regulation of RhoB, we synthesized novel aliphatic amido/sulfonamido-quaternary ammonium salts and evaluated their biological activities using an in vitro growth inhibition assay and RhoB promoter assay in human cancer cells.
The computer analysis of relations between molecular structures and their biological activity using fragment-based methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates.
In this study, we set out to establish NPDFs as powerful seeds for the de novo creation of organic molecules with tailored biological activity using matrix metalloproteinase 13 (MMP-13) as an exemplary target.
The present work is devoted to design of capsules with hydrophilic drugs such as insulin to preserve its stability and biological activity using the double emulsion technique and its subsequent entrapment into biodegradable microcapsules with shells made of Chitosan and Xanthan Gum complexes.
