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The computer analysis of relations between molecular structures and their biological activity using fragment-based methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates.
Our in-depth, large-scale mapping of novel glycosylation sites represents a crucial step toward systematically revealing the functionality of N-glycosylated RJ proteins, and is potentially useful for producing a protein with desirable pharmacokinetic and biological activity using a genetic engineering approach.
Extracts created from both materials were evaluated for biological activity using in vitro cell culture assays.
The present work is devoted to design of capsules with hydrophilic drugs such as insulin to preserve its stability and biological activity using the double emulsion technique and its subsequent entrapment into biodegradable microcapsules with shells made of Chitosan and Xanthan Gum complexes.
For this purpose we investigated the biological activity using a broad variety of cancer cell lines in vitro and, importantly, the well established C3 mouse model in vivo.
Each Wnt3a mutant was first tested for its biological activity using a Wnt reporter assay.
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Summary: The previously disclosed QuantMap method for grouping chemicals by biological activity used online services for much of the data gathering and some of the numerical analysis.
For example, one publication defined the placebo as "a sham treatment, such as a pill, liquid, or injection without biological activity, used in pharmacology to control for the activity of a drug.
Current therapeutic strategies for targeting MIF focus on inhibiting its signaling activity by small molecules or modulating its biological activities using anti-MIF neutralizing antibodies.
We characterized differences between the effector cells and compared ADCC biological activities using the well-known humanized IgG1 antibody drug, trastuzumab.
Based on a piperazine alkyl derivative that induced apoptosis via up-regulation of RhoB, we synthesized novel aliphatic amido/sulfonamido-quaternary ammonium salts and evaluated their biological activities using an in vitro growth inhibition assay and RhoB promoter assay in human cancer cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com