Pyrans and pyran-annulated heterocyclic scaffolds possess a broad spectrum of significant biological activities that include anticancer, cytotoxic, anti-HIV, anti-inflammatory, antimalarial, antimicrobial activity [105, 106, 107].
Imidazole and its derivatives possess a wide-range of biological activities that include anti-inflammatory [65], anti-tumor [66], anti-fungal [67] efficacies.
The synthesis of different thiazole derivatives has attracted great attention due to their diverse biological activities that include anticonvulsant [1, 2], antimicrobial [3, 4], anti-inflammatory [5, 6], anticancer [7], antidiabetic [8], anti-HIV [9], anti-Alzheimer [10], antihypertensive [11], and antioxidant activities [12].
The inflammatory mediator PGE2 exerts a range of biological activities that include stimulation of inflammation-associated bone resorption (5).
Alkylated diamines and amino alcohols have been reported to possess a wide range of biological activities that include antibacterial, leishmanicidal, and trypanocidal [ 10– 17].
3-FTx exert a variety of biological activities that include blockade of acetylcholine (nicotinic and muscarinic) receptors, β-adrenergic receptors, L-type calcium channels and integrins, inhibition of acetylcholinesterase, and cardiotoxicity mediated by interation with phospholipids.
13 They show a highly significant profile of biological activities that typically include strong antioxidant and radical scavenger functions, but also comprise antiviral and cytotoxic effects.
GW974 does have strong biological activities that probably work through Met, including the inhibition of wound healing after scratch injury of a cell monolayer.
TIMPs also have biological activities that are independent of metalloproteinases; these include effects on cell growth and differentiation, cell migration, anti-angiogenesis, anti- and pro-apoptosis, and synaptic plasticity.
Histamine, which is stored and released by mast cells, has wide-ranging biological effects that include proangiogenic activity [ 48].
Additionally, phenolic compounds are commonly found in plants and have been reported to have multiple biological effects that include antioxidant activity [ 54– 54].
