Thus, a range of software tools have been developed that allow to correlate the structure of a chemical scaffold and biological activities for example by utilizing chemical structure based hierarchical ontologies.
With the Gaussian vector space kernel, we can apply a kernel-based method to generate a predictor of any one of several biological activities, for example: ADMET properties or affinity of ligands used as therapeutic agents.
Unfortunately, the report does not address the effect of altered cleavage on fractalkine's biological activities, for example, chemotaxis.
Cyanobacteria have been identified as sources of bioactive compounds with interesting biological activities, for example, antibacterial, antifungal, antiviral, antialgal, anticancer, anti-inflammatory, and so forth.
Apart from mediating growth factor activities, HS also functions as coreceptors in other biological activities, for example, modulating the interaction of neuropeptide agouti-related protein with melanocortin receptors 3 and 4 (MC3R and MC4R) in the hypothalamus and regulating food consumption [ 6– 8].
As RANTES/CCL5 is involved in various physiopathological processes, the development of a new therapeutic strategy may be reliant on the mechanism by which RANTES/CCL5 exerts its biological activities, for example by targeting the binding of the chemokine to its proteoglycan receptor.
Oxidized derivatives of cholesterol with biological activity, for example, as binding partners for nuclear receptors.
First, the gypsum has greater volume and greater porosity, so it will hold more acidic water at the surface, continuing the acid attack on the underlying stone and encouraging other destructive processes such as biological activity (for example, the growth of mold).
Thirty-seven of the 60 validated compounds had known biological activity (for example, inhibitors of protein synthesis and topoisomerase activity, antibiotics and antihelmintics).
Even when modeling leads to the characterization of particular molecule fragments related to toxicity, it is not easy to build a precise mechanistic interpretation for their role in biological activity (see for example [19]).
The major factor controlling dissolved oxygen concentration is biological activity; thus for example, photosynthesis producing oxygen while respiration and nitrification consume oxygen (although under hypoxic or anoxic conditions, denitrification can be a source of oxygen) (Best et al. 2007).
