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Interventions Biologic strategy: start tumour necrosis factor inhibitor; second biologic in six month for non-responders.
As such, this hypothesis presents a biologic strategy for identifying potentially significant neurotoxic mixtures for hazard identification in future studies.
Initial reductions in disease activity were greater with the biologic strategy, but these differences did not persist beyond six months.
Main outcome measure Primary outcome: reduction in disability at 12 months measured with patient recorded heath assessment questionnaire (range 0.00-3.00) with a 0.22 non-inferiority margin for combination treatment versus the biologic strategy.
To further support this notion of broader amelioration with multi-pathway inhibition, dual JAKi + SYKi also resulted in higher efficacy than anti-TNF therapy, the most common first choice biologic strategy (ACR guidelines 2012) (Fig. 3).
Remission was seen in 72 patients (44 with biologic strategy; 36 with alternative strategy); 28 patients had serious adverse events (18 and 10, respectively); six and 10 patients, respectively, stopped treatment because of toxicity.
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Several different biologic strategies to block BAFF/BLyS and APRIL are being developed.
During the last century the management of primary breast cancer has evolved from gross surgical intervention to a sophisticated approach involving surgical, radiotherapeutic, hormonal, chemotherapeutic, and targeted biologic strategies.
Medarex's technology platform, people and pipeline provide a strong complement to our company's biologics strategy, specifically in immuno-oncology.
James M. Cornelius, chairman and chief executive officer, Bristol-Myers Squibb (BMS) noted about their $2.1 billion acquisition of Medarex: Medarex's technology platform, people and pipeline provide a strong complement to our company's biologics strategy, specifically in immuno-oncology.
Concordantly, the most investigated biologic drug strategy in humans for gouty inflammation has been neutralization of IL-1, with promising results [ 9, 17].
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