However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB permeable.
biologic or biological #16.
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After being mixed with granular cathelicidin antimicrobial peptides, it is actively extruded by the neutrophil as a type of biologic "spiders web" into the extracellular space or tissue.
However, due to progressive glenohumeral space narrowing, the durability of biologic soft tissue interposition grafts may present a long-term concern [ 21].
Many studies document the hydrologic, biologic, or geomorphic consequences of urbanization using space-for-time comparisons of disparate urban and rural landscapes.
The diverse biologic activity and coverage of a broad chemical space make barbituric acid and thiobarbituric acid derivatives excellent target compounds for organic and medicinal chemists.
Compared to the list of genes whose steady state was altered by OA, there was a lesser enrichment of genes associated with extracellular space and ECM location, although the biologic properties were similarly varied.
We examine the emergence of a new regulatory 'regime' in Europe and the social shaping of a regulatory space between medicinal products, medical devices and biologics where these innovative products may be situated.
The application of SAFES methodology to dehydration of apple by combined methods requires considering it as a biologic system constituted by cells which assemble in a tissue including intercellular connexions, intercellular spaces and pores.
Supporting this line of reasoning is the biologic relevance of the two proteins (clusterin and lubricin) for which the tryptic peptides in plasma best predicted joint space narrowing in a combined biomarker score.
