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Our goal was to discuss the biologic rationale for the use of specific herbs (silymarin, glycyrrhizin, sho-saiko-to, Phyllanthus amarus, Picrorrhiza kurroa, Compound 861, CH-100, and LIV.52) in the treatment of chronic liver diseases, as well as the evidence for their efficacy and adverse effects according to clinical trials.
Therefore, there is a biologic rationale for the separation of these 2 genetic effects.
There is a strong biologic rationale for the hypothesis that the Fas pathway is important in AKI, as outlined above.
The modified H-score (hereafter referred to only as H-score) was calculated for those cell compartments for which specific staining was identified and a biologic rationale for the subcellular location of the respective marker existed (for example, for PTEN, nuclear staining is reported to contribute specifically to its tumor suppressor function).
This review summarizes the molecular biologic rationale for the adenovirus mutant dl1520 (now designated ONYX-015 or CI-1042), whash has been used to test the possibility of tumour-selective virus replication and it summarizes the ongoing debate over the basic mechanisms involved in replication of ONYX-015.
This article reviews several underlying mechanisms thought to be responsible for the association between hyperglycemia and poor outcomes in critically ill patients and those with cardiovascular events, as well as the biologic rationale for the benefits of insulin therapy in these patients.
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There is some biologic rationale for this effect, since the mechanism of action for bisphosphonates is inhibition of osteoclast activity.
The biologic rationale for this finding is uncertain.
Biologic rationale for this association is consistent and could lead to the improvement of our knowledge of endometriosis pathogenesis.
Although patients with pN2 or pN3 disease have a clearly worse prognosis than those with pN1 disease (Axelsson et al, 1992; Kim et al, 2006), the biologic rationale for four nodes as the threshold between pN1 and pN2 is unclear.
We will focus on the biologic rationale for targeting novel pathways regulated by Bcl-6, Bcl-2, BLysS, and APRIL for example.
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