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Identifying the corresponding biologic processes that are responsible for disease and its outcome remains challenging.
Although the exact mechanism for the tissue and process specific miRNA mRNA co-expression observed in the CNS remains to be clarified, our findings point to biologic processes that are likely part of the mechanism of interest.
As evident from the examples above, assessment of differentially expressed genes with known functions is useful to monitor pathways or biologic processes that are triggered in expression profiling experiments.
As an important regulator of cellular proliferation, differentiation, inflammation, and angiogenesis, the nuclear factor kappa B (NFκB) family of transcription factors likely regulates many of the biologic processes that are essential for alveolarization.
The major findings from this analysis were that 1) insulin secretion, and other biologic processes that are retained with younger age, are key in the restoration of NGR in people with pre-diabetes; however, 2) NGR may also be attained through weight loss and additional aspects of ILS, such as healthy eating and exercise.
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Fetal growth is a complex biologic process that is regulated by both maternal and fetal factors including genes and environment.
The three longitudinal studies indicating that cholesterol and PFOA were related over time in subjects with repeated measurements (Costa et al. 2009; Olsen et al. 2003; Sakr et al. 2007b) strengthen the case for a causal relationship, although they do not preclude a relationship in which both PFOA and cholesterol jointly covary with some biologic process that is also changing over time.
Further analysis of these genes may inform us about biologic processes that can be used to identify intracellular targets of potential therapeutic benefit for patients with this disease.
In the work presented here, we provide a means for objectively identifying the biologic processes that may be the target of these alterations.
Apoptosis is a fundamental biologic process that could be described as controlled demolition of cell and is inherent in every cells and plays vital roles in numerous medical disorders [ 1, 2].
The authors conclude that there are five key biologic processes that warrant further investigation: inflammatory and immune responses, cell proliferation, chemotaxis, and blood coagulation.
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