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The study also revealed a key role of the surfactant coating as well as the influence of the nanoparticle composition on their biologic performance, i.e. poloxamer 188 appeared to be more effective as a coating agent than polysorbate 80, and the nanoparticles stabilized by PVA appeared to be more effective than those stabilized by HSA.
In particular it remains unclear whether differences in the major histocompatibility complex (MHC) influence incorporation of bone allografts and their subsequent biologic performance.
Torabinejad et al. [ 36] reported a favorable biologic performance of MTA when in direct contact with bone, through the deposition and formation of hydroxyl apatite on its surface.
Antibodies against human leukocyte antigen (HLA) are induced by mismatched bone transplants [ 10, 30, 32], but it remains unknown whether donor-specific HLA sensitization influences the incorporation of bone allografts and their subsequent biologic performance.
As stated earlier, the clinical value of biomarkers is based on their properties to satisfy the goals of early detection (screening), surveillance in terms of early and later progression, and monitoring of the biologic performance of an AAA after surgical treatment.
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On the contrary, the differences in study population characteristics are too marked in late RA for an adequate comparison of biologics performance in this clinical condition.
Sixteen main registrative RCTs evaluating the performance of biologic agents in slowing RA structural damage can be found in the literature.
biologic or biological #16.
(biologic or biological).ti,ab.
Finally, several design examples are also given to confirm the robust desired behavior tracking performance of synthetic biologic circuits with intrinsic genetic variations and environmental disturbances by the proposed evolutionary systems biology design method through the EA searching algorithm.
We hypothesise that detection of ERCC1 202 underlies prognostic performance; however, the biologic underpinnings of this clinical association require further elucidation.
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