Sentence examples for biologic pathways such as from inspiring English sources

Physical activity may protect against bladder cancer through several biologic pathways, such as enhanced immune function and decreased chronic inflammation.

GSTP1 also physically interacts with other molecules and contributes to other biologic pathways, such as c-Jun N-terminal kinase (JNK), a protein kinase involved in transcription of cytokines, immunoglobulins (e.g., IgE), and inflammatory enzymes, and 1-cystein peroxiredoxin (1-Cys Prx), which catalyzes reduction of peroxides (Bennett et al. 2001; Ralat et al. 2006).

Oxidative stress initiates complex biologic processes in various layers of the skin, which can result in transient or permanent genetic damage, activation of transcription factors, such as Ap1 and NF-κB, and signaling pathways, such as the ERK, JNK, and p38 MAPK pathways, involved in cell growth and differentiation and in degradation of the connective tissue of the dermis.

CKIε has been shown to be important in several biologic activities including the circadian clockwork (Lee et al, 2009), developmental polarity (Tsai et al, 2007) and in phosphorylating key proteins in cancer signalling pathways such as p53 and β-catenin (Gao et al, 2002; Meng et al, 2010; Seifert & Mlodzik, 2007; Yang & Stockwell, 2008).

Microarray technology may revolutionize the field of toxicogenomics by helping scientists target new drugs, discover gene function, determine biologic pathways, and better understand diseases such as cancer, cystic fibrosis, and cardiovascular disease at the molecular level.

Standard inhibitors of the WNT signaling pathway include biologic inhibitors, such as small interfering RNAs, antibodies, and recombinant proteins, and chemical inhibitors, such as NSAIDs, vitamins, and polyphenols, that have fairly general (or unknown) targets [ 1, 3, 4].

Particle-induced osteolysis has been shown to follow a biologic pathway, driven by cytokines such as interleukin (IL -1β, IL -1βand tumor necrosis factor (TNF)-α.

Although promising results have been demonstrated with these medications, the blockade of such important biologic pathways necessitates careful safety monitoring.

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biologic functions such as transcriptional and translational control.

The presence of common cytokine pathways certainly explains the utility of several biologic therapies, such as TNF blockers, in a number of chronic arthropathies.

Our study demonstrates that different signaling pathways will play dominant roles in individual steps which are involved in a complex biologic process, such as angiogenesis.