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We exploit new discoveries at all levels of biologic organization, from the molecule to international populations.
The effects we have documented at multiple levels of biologic organization combine to provide real insight into the effects of long-term contaminant exposure on wildlife populations.
Inhibition of CYP1A induction in its own right may have important consequences for the resistant population, but is it predictive of decreased sensitivity of Hudson River tomcod to toxicities at higher levels of biologic organization?
Advantages of invertebrates in ecotoxicologic investigation are presented for their usefulness for seeking mechanistic links between effects occurring at the individual level and consequences for higher levels of biologic organization (e.g., population and community).
This theme encompassed the potential to link gene expression changes to specific biologic pathways that includes higher levels of biologic organization, from protein expression through pathology, as well as the promise of in silico modeling and the ability to test chemicals for toxicity without the use of animals.
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Arising of biologic cellular organization and genetic mechanisms is, under this scenario, the result of prebiotic chemical evolution.
From here, biologic entities or organizations may either undergo the final exponential uncontrolled growth or enter the path of self-destruction.
The structural and functional dilemmas of being in the zone of chaos have to be eventually resolved by the biologic entities or organizations, either by returning to physiologic oscillations or by allowing the disorganized complexity to eventually overcome a system.
Resetting also is a stimulus that can propel a biologic entity or an organization from one zone to another.
Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span.
It may be attributable to other population factors, changes in HES coding, changes to health service organization, other biologic phenomenon, or a combination of these effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com