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However, many of these tools require the direct modification of the active biologic of interest [92].
We identified patients included in the Medco PBM database with one or more claims for a biologic of interest (abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, or tocilizumab) from July 1 , 2007 to July 31, 2012.
Observation was ended at either 1.0 year after the start of the observation period, or on the date of death of a patient, loss to follow up, enrollment in clinical trials, when therapy with a biologic of interest was discontinued for more than 90 days, or on 5 March 2012, whichever came first.
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Biologics of interest included abatacept, adalimumab, etanercept, infliximab and rituximab.
Biologics of interest with <100 eligible patients were excluded from the final analysis because of small sample size.
The overall cancer risk in those taking adalimumab was slightly lower than in those taking etanercept, either in the patterns of treatment alone, ever-treated or last-treated with the biologics of interest, yet without statistical significance (Table 4, Additional file 2: Table S2).> -wrap-foot> Cancers of digestive system include cancers of the stomach, colon, liver, pancreas.
The risk of non-Hodgkin's lymphoma was comparable between those taking adalimuamb and those taking etanercept, either in the patterns of treated alone, ever-treated or last-treated with the biologics of interest, without statistical significance (Additional file 2: Table S2).
The advantage of the functional screening approach is that the method defines the identification of genes involved in the biologic response of interest, in this case neuroprotection.
Patients could be included in more than one cohort depending on their use of the biologic agents of interest.
Because these chemicals are nonpersistent, knowledge of intraindividual reliability over the biologic window of interest is also required.
This framework combines human and laboratory studies and incorporates new technologies, as appropriate, to answer the biologic questions of interest.
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