Sentence examples for biologic loss from inspiring English sources

Aseptic loosening can be the result of inadequate initial fixation, mechanical loss of fixation over time, or biologic loss of fixation caused by particle-induced osteolysis around the implant.

Before suppression of disease activity by biologics, bone loss might already be advanced.

These technologies range from the exploitation of innate in vivo functions to target and repair damaged tissue, to removal and purification of hMSC for use in numerous other settings such as tissue engineering, cell therapies, etc. Essential to these developments is the ability to process and maintain these unique biologics without the loss of viability and functionality.

Failure of the autonomic nervous system can be associated with loss of biologic complexity.

Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation.

Mutations in the region 1 21 are tolerant to changes without the loss of biologic activity; in contrast, changes in amino acids 25 40 are generally deleterious for transactivation.

Use of lower pH buffers were not used in order to avoid loss in biologic activity of the HSP72 ligand.

Nonetheless, a number of studies have found plausible biologic associations with cartilage loss on MRI in this dataset, including relations to alignment [ 40], bone marrow lesions [ 41], and meniscal abnormalities [ 42].

Use of endostatin in clinical trials in cancer therapy has been hampered by difficulties in protein production in large quantities, loss of biologic activity during long-term storage, and cumbersome daily administration requirements.

The biologic effects of the loss of BRCA1 gene function caused by promoter hypermethylation and by coding-region mutations in breast and ovarian cancer produce similar microarray patterns of reduced gene expression (Hedenfalk et al, 2001).

As well as influencing disease activity, biologics may prevent bone loss via a direct effect on bone metabolism.