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Simply dissecting and then homogenizing a rat liver in a typical laboratory blender can result in chromium contamination many times the actual biologic level in the sample.
Epidemiology could benefit from entering the "big data" arena and has begun to do so with studies at the biologic level.
To properly ascertain the risk of a given biologic level of a chemical will require well-controlled studies that demand resources, time, and careful planning.
The goal of this later model is to try to explain and understand at a biologic level what has been observed.
Biological data mining approaches, particularly those related to artificial intelligence and machine learning, could address current epidemiologic limitations and are starting to be explored in population-based studies that include patient and biologic level data [ 5, 6].
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The current study evaluated whether exposure to low levels of lead acetate over longer periods of time would produce a similar pattern of adaptation to toxicity at the molecular and biologic levels.
The Mount Sinai center collected urine samples in the third trimester of pregnancy and found that approximately 70% of the women in the cohort had been exposed to pesticides, but no associations were found between these biologic levels and pesticide questionnaire data (Berkowitz et al. 2003).
Hierarchical analysis of enriched categories from the parent GO terms (levels 1 2) down to categories describing more specific biologic processes (levels 3 9) revealed a number of functions and pathways relevant to the biology of airway basal cells.
To examine the effect of second-hand smoke exposure on biologic exposure levels, we performed a stratified analysis of 1-OHP urinary levels and city of residence (Table 5).
In this RRT population, all biologic marker levels except PAI did not improve clinical prediction of events.
To our knowledge, this is the first study that evaluates biologic drug levels at first inadequate response and their relation to further clinical response in patients with RA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com