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Since the biologic function of the HLA molecules is presenting endogenous and exogenous antigens, they manifested high structural polymorphism.
Therefore, in the case of MSP142-based vaccines investigators may need to consider other assay(s) to evaluate the biologic function of the induced antibody.
To explore the biologic function of the differentially expressed miRNAs identified in our analysis, we performed computational analysis using four independent algorithms, including TargetScan, miRanda, RNAhybrid and PicTar, for identification of predicted messenger RNA targets for each miRNA to be significantly differentially expressed.
To further examine the biologic function of the ERBB2 gene set, we performed Ingenuity Pathway analysis (IPA).
The biologic function of the Gsdm/GSDM family genes initially was inferred from phenotypes of spontaneous and chemically-induced mouse mutants.
The present study supports the notion that TNF-α utilizes EGFR signaling to mediate physiologic effects [ 11, 20], and raises the possibility that targeted inhibition of one pathway may influence the biologic function of the other.
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For this reason we believe it is important to consider potential pathway interactions when evaluating the biologic function of these proteins.
Hence the biologic function of these proteins remains to be elucidated.
The biologic function of this glutamine-rich region is currently unknown, however, and to our knowledge no studies have correlated this AIB1 repeat polymorphism with coactivator activity.
In a nutshell, the process relies on the fact that amino acid sequences surrounding phosphorylation sites within specific proteins along with the biologic function of those phosphorylation events—are often conserved from one species to another.
However, biologic function of these mediators is mediated by signaling pathways.
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