Exact(5)
The programme is one of the largest to date in PsA patients who have prior DMARD and/or biologic experience.
44 99 Other factors that increased the likelihood of a biologic monotherapy prescription included the patient's previous biologic experience and the rheumatologist's prescribing patterns.
Efficacy was observed with apremilast regardless of prior biologic experience or concomitant DMARD use, with a higher absolute rate of ACR20 response in biologic-naïve patients.
The FDA previously developed the Coding Symbols for Thesaurus of Adverse Reaction Terms (COSTART) [ 11], which was used for coding, filing, and retrieving post-marketing adverse drugs and biologic experience reports.
As would be expected, relative to the overall population, patients with biologic experience tended to have a longer duration of both PsA and psoriasis, a greater proportion had baseline psoriasis body surface area ≥3%, and a lower proportion were taking concomitant DMARDs at baseline.
Similar(55)
In an analysis of PBM claims data, we found that patients with RA who took subcutaneous biologics experienced a higher rate of effectiveness according to a validated algorithm and lower cost per algorithm-defined effectively treated patient.
Physicians should proceed cautiously when considering the use of combinations of biologic agents; experience with this approach is very limited at this time and may have unknown consequences.
Prespecified health events of interest were identified collectively by study investigators based on biologic plausibility and experience with other vaccines.
Nevertheless, a biologic caregiver may experience a stronger emotional connection with the child and be more motivated to promote better adherence compared with a non-biologic caregiver [ 8].
One could argue that although siblings are excellent controls for biologic outcomes, their experience of transplant could influence their psychosocial outcomes in a manner not detected.
Whilst our understanding of biologic and social experience in early risk mechanisms for poor development in the preterm population is incomplete, [ 4- 7] there is growing evidence early intervention (EI) can mediate risk and improve lifespan outcomes [ 8- 10].
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