Exact(2)
Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases.
Given the non-negligible risk of failure of molecular risk evaluation using FFPE specimens and the importance for ongoing biologic discovery during prospective studies to provide validated data for new prognostic factors and therapeutic targets, fresh-frozen tissue will continue to be mandated for enrollment on the SIOP-E PNET 5-MB study.
Similar(58)
Advances in microscopy have contributed to many biologic discoveries.
These biologic discoveries have enabled additional scientific and engineering innovations that have given rise to technological advances in biologic manufacturing.
Five phases of moving genomic research into practice and policy have been defined, with the early phases focusing on biologic discoveries (T0), development of candidate health applications (T1), and assessing outcomes of interventions (T2).
11, 12 In addition, polymorphisms in AChR alpha (CHRNA1) have been shown to confer increased risk to very early-onset MG. 13 In the past 5 years, important biologic discoveries have come from genome-wide association studies (GWAS) aimed at unbiased detection of variants at loci predisposing to complex traits, such as cardiac, autoimmune diseases, and psychiatric disorders.
Consistent and robust performance at a wide range of scales is important for using a system as a general production technology and the time and cost of biologic drug discovery and production process development can be substantially reduced with systems that scale in a predictable and efficient manner from high-throughput screening to manufacturing.
Nanoparticle harvesting has applications to the proteomic analysis of body fluids beyond blood, such as urine [37], cerebrospinal fluid, and amniotic fluid, which are promising biologic sources for biomarker discovery and measurements [52], [53].
This clearly reflects the recent increased pharma interest in discovery of biologics [7], which build on the premise of a personalized treatment [8].
biologic or biological #16.
(NIPAm/AAc core NIPAm shell hydrogel particles have been synthesized and successfully applied to harvest, concentrate, and protect from degradation, PDGF and various chemokines, low abundance labile clinical biomarkers from model solutions and serum, a known complex biologic fluid targeted for biomarker discovery.
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