Tendon-bone interface tissue is extremely challenging to engineer because it exhibits complex gradients of structure, composition, biologics, and cellular phenotypes.
There was no other noticeable consistency in wind pattern, speed, or direction that could be linked to specific particle composition and biologic effects.
DeMarini et al. (2004) and Singh et al. (2004) highlighted the chemical, physical, and biological differences between two widely used DEP samples, one mainly studied for pulmonary toxicity and the other for genotoxicity; before their studies, the chemical composition and biologic activity of the samples had not been compared.
Our results not only suggest that mechanistic studies of the health effects of ambient air need to consider both phases as having the potential to induce and/or inhibit AHR and ER signaling pathways but also suggest that the relationship between chemical composition and biologic activity is highly complex.
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The remaining chemical and biologic assays confirmed the purity, composition, and functional activities of the molecule.
The study also revealed a key role of the surfactant coating as well as the influence of the nanoparticle composition on their biologic performance, i.e. poloxamer 188 appeared to be more effective as a coating agent than polysorbate 80, and the nanoparticles stabilized by PVA appeared to be more effective than those stabilized by HSA.
Imbalances in the biologic carbon cycle can change the composition of the atmosphere.
The apatitic phase obtained by the hydrolysis reaction was more similar to the biologic one, in terms of chemical composition, crystallinity and specific surface than the hydroxyapatites obtained by sintering.
Not only does the presence of non-standardized glycoforms pose a risk, but the technology to routinely determine composition equivalence between a biologic originator and subsequent biosimilars is not yet available.
