Sentence examples for biologic combination from inspiring English sources

Minimal literature on the effectiveness of biologic combination therapy is available, warranting the need for studies evaluating the combination of two biologics for PsA [ 169– 169].

We evaluated the safety and hemostatic efficacy of a new advanced biologic combination product―fibrin pad―to potentially address some gaps associated with TAHs.

The Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE-JIA) trial published in 2011 compared biologic combination therapy [methotrexate plus tumor necrosis factor (TNF α inhibitor], conventional synthetic DMARD combination (methotrexate, sulphasalazine and chloroquine) or methotrexate alone.

49 Observational data confirmed these analyses showing similar efficacy of biologics combination therapy in TNFi-IR.

One of the groups began talking to the FDA before the Office of Combination Products (OCP), which handles device-drug or device-biologic combinations, was established.

In addition, more than 92% of patients in the biologics group received biologics in combination with nbDMARDs or corticosteroids after the index date.

All RA patients failed respond to methotrexat (MTX) treatment and received abatacept as first-line biologic in combination with MTX.

Thus, robust evidence for high risk of methotrexate failure would allow clinicians to argue for an early use of biologic, in combination or alone.

bOf the patients who took the biologic in combination with a csDMARD, methotrexate was the comedication in 75.0% of patients in the abatacept group, in 91.4% in the rituximab group and in 86.0% in the TNFi group.

The EULAR Task Force recommends the use of all biologics in combination with MTX 2; however, registry data estimate that approximately one-third of patients are receiving biologics as monotherapy.

As innovative as biologic-device combination products are, they can pose considerable development, regulatory, and commercialization challenges due to unique physicochemical properties and special clinical considerations (e.g., dosing volumes, frequency, co-medications, etc). of the biologic medicine.