Obesity and a sedentary lifestyle are associated with physical impairments and biologic changes in older adults.
Post-glacial environmental changes were identified as stratigraphic or biologic changes in select cores.
Despite efforts from advocacy groups and individual patients to increase awareness — as well as empirical evidence linking psychiatric disorders and treatments to biologic changes in the brain — there's the nagging sense that many psychiatric diagnoses may be arbitrary and subject to social conventions, or that many affected patients could, with a little willpower and hard work, get better.
Each puff of cigarette smoke contains >1014 oxidant molecules and >1000 xenobiotics [2], and exposure to cigarette smoke evokes significant biologic changes in the airway epithelium, even though many smokers are phenotypically normal [3] [6].
Thus, the most likely explanation for the observed changes is true biologic changes in the pulmonary proteome in response to LPS.
Additionally, accumulation of biologic changes in host tissue may result in unacceptable toxicities that necessitate dose interruptions or reductions, resulting in decreased dose density and potentially lower efficacy.
More importantly, PD biomarkers may reflect biologic changes in tumor and host tissues in response to treatment and are potentially useful for patient monitoring.
These biologic changes in response to atacicept are associated with reduced disease scores and prolonged survival in SLE-prone mice [ 19, 29, 30, 32].
Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs).
The change in IL-17A levels pre/post biologic therapy strongly correlated with the change in CRP (r2 = 0.817, P < 0.01) and the change in A-SAA (r2 = 0.627, P < 0.05), markers of the acute phase response.
