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A better understanding of the biologic basis of the dose-dependent elimination of TCDD would allow for the development of more biologically realistic PBPK models.
What is the possible biologic basis of the observation that proximity to agricultural land use is associated with risk for amphibian limb malformation?
Even though the biologic basis of the association between MD and BC is not fully understood, breast density is increasingly used as a phenotype risk marker [ 5].
Furthermore, understanding the biologic basis of the association has the potential to lead to new therapeutic targets to reduce the burden of late-life motor impairment.
A number of questions remain regarding the biologic basis of the heterozygote advantage for recessively inherited AID-related genes or the natural selection of mutated genes related to dominantly-inherited AID.
It is a matter of fact that the greatest advances in the development of successful clinical treatments have been achieved based on a more precise understanding of the functional biologic basis of the particular disease.
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The different approaches used to describe the dose-dependent induction of TCDD elimination are due to a lack of understanding of the biologic basis of these phenomena.
Though initial results demonstrate that neoplastic tissues can be discriminated from normal mucosa by NCF analysis, the biologic basis of this difference remains uncertain.
Each method identified both well established and novel mechanisms of disease pathogenesis, and because the biologic basis of each of the methods is unique, the methods are complementary, with each highlighting a different aspect of the disease.
An understanding of the biologic basis of oligometastases has the potential to improve patient care through diagnostics and therapeutics.
A review of the current scientific implications for the biologic basis of SLE pathogenesis and the therapeutic management of the disease will increase rheumatologists' medical understanding of the molecular and cellular basis of SLE pathogenesis that is crucial to improving outcomes in these patient populations.
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