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Therapeutic drug design targeting TNF has led to the emergence of successful biologic agents, such as etanercept, in recent years.
Biologic agents such as infliximab (IFX) have been shown to be highly efficacious in treating immune disorders such as inflammatory bowel disease and rheumatoid arthritis.
Biologic agents such as bevacizumab and erlotinib have been investigated in phase III trials in the first- and second-line setting.
There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears.
Additionally, not all immunomodulatory drugs currently used to treat uveitis were included in the survey; omitted treatments include the calcineurin inhibitors tacrolimus and sirolimus, the alkylating agent chlorambucil, and newer biologic agents such as golimumab or certolizumab.
The introduction of biologic agents such as tumor necrosis factor-alpha (TNF-α) antibodies and interferon alpha (IFN-α) provides a new intervention regimen for patients with refractory uveitis [3], [4], [5].
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Another therapeutic option is to switch to a different class of biologic agent such as rituximab, tocilizumab or abatacept [ 4- 6].
For example, find earliest instance of rheumatoid arthritis diagnosis or find latest pharmacy record (prescription, renewal, or discontinuation) for a biologic agent such as infliximab.
Filtering face piece respirators are usually tested utilizing nonbiologic particles, whereas their use often aims at reducing exposure to biologic aerosols, including infectious agents such as viruses and bacteria.
Poliovirus presents a low level risk as a potential biologic agent relative to agents such as smallpox and anthrax.
Newer agents such as biologic response modifiers hold great promise for the treatment of OID, but may also have increased risks [9].
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