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This part was mostly done using an in-house bioinformatics tool based on the following criteria and definition: 1) A methylation peak of a sample is the methylated region shared between the two biological replicates of the same sample.
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The relationship between the mutations and epitopic functions are investigated with bioinformatics tools, based on their sequence information.
Moreover we discuss some bioinformatics tools based on their type, methodology and usage.
The generated reads are then treated with bioinformatics tools based on prior knowledge of tested GMO.
Bellman's GAP is a new programming system, designed to ease the development of bioinformatics tools based on the dynamic programming technique.
To test the potential deleterious effects of the p.Thr411Ile and p.Arg477His, we first used bioinformatic tools based on heuristic methods for predicting pathogenic variants.
The pathogenicity of the human mutations was predicted by using five bioinformatic tools based on heuristic methods: PANTHER (http://www.pantherdb.org), SIFT (http://sift.jcvi.org), PolyPhen-2 (http://genetics.bwh.harvard.edu/pph2), SNPs&GO (http://snps-and-go.biocomp.unibo.it/snps-and-go), and MutPred (http://mutpred.mutdb.org).mutdb.org
The third variable (V3) region of gp120 is responsible for the differential CXCR4 or CCR5 co-receptor binding to HIV-1, and genotypic methods and bioinformatic tools based on V3 sequencing have been developed to facilitate the prediction of co-receptor tropism (CRT) [ 1].
To address this, we developed BALL-SNP, a novel tool based on the Biochemical Algorithms Library BALLL) [ 12], a molecular modeling framework, which provides robust and sophisticated algorithms on structural bioinformatics.
Bioinformatics tools also based on statistical and ML algorithms are able to utilize these data.
HMMER is a widely used tool in bioinformatic, based on the Profile Hidden Markov Models.
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