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Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups.
Our study provides insights into the mechanism of modulus-driven cellular behaviors for better design of bioengineered cell substrates.
In contrast to previous materials such as fibrin glue, these bioengineered cell sheets immediately and permanently seal air leaks in a dynamic fashion that allows for the extensive tissue contraction and expansion involved in respiration, without any postoperative recurrences.
In animal models, cell-transplant analgesia has proven successful both with cells from primary tissue (mostly in studies with adrenal medullary chromaffin cells) and with immortalized, bioengineered cell lines that secrete pain-reducing neuroactive substances.
Bioengineered cell culture environments that combine microenvironmental control with tissue-specific transport and signaling are critical tools in our efforts to study tissue development, regeneration, and disease under conditions that predict the human in vivo context.
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Finally, the performance of this bioengineered cell-based biosensor was evaluated.
In this study, we explore the feasibility of using a label-free bioengineered cell-based biosensor to detect salicin.
All the results demonstrate this bioengineered cell-based biosensor can be used to detect the interactions between chemical receptors and their ligands.
This bioengineered cell-based biosensor exhibits the sensitivity of 1.0 mV/s for hT2R4 assays, and 9.8 mV/s for ODR-10 assays.
This study described a novel bioengineered cell-based biosensor for label-free functional assays of chemical receptors by localized extracellular acidification measurement with a light-addressable potentiometric sensor (LAPS).
The obtained results indicate that both of chemical receptors were successfully expressed in HEK-293 cells and can be functionally assayed by this bioengineered cell-based biosensor that shows dose-dependent responses to the target ligands of chemical receptors.
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CEO of Professional Science Editing for Scientists @ prosciediting.com