It enables biochemical cellular targets, such as cell-specific receptors, and more general metabolic processes to be targeted with tracers coupled to radionuclides for sensitive imaging.
For example, there is increasing confidence that fragment-based approaches offer improved opportunities for screening against difficult targets, such as protein protein interactions, that standard biochemical HTS cannot offer [42].
The extension of their use to new neglected disease targets, such as leishmaniasis, requires an understanding of their biochemical targets in the parasites.
At the biochemical level, the KD binds to ATP as the only ligand, whereas the PBD binds to a large spectrum of binding targets, such as Plk1-binding proteins and physiological substrates (Park et al. 2010).
Curcumin is known to target multiple biochemical pathways, such as those mediated by Wnt/β-catenin [ 26], NF-κB [ 20], growth factor receptors like EGFR and HER2 [ 27], and JAK/STAT [ 28] enhancing its effect on cancer cells.
This model is well-suited for identifying and testing drugs that target highly-conserved biochemical mechanisms, such as sumoylation, which oversee self-renewal pathways in progenitor populations.
In non-Drosophilids, mosquitos produce Yp in response to a blood meal that also implicates hormonal signalling from ecdysone as well as biochemical pathways such as the Target-of-Rapamycin (TOR) pathway (reviewed in [ 13]).
In fact, although paralogues and orthologues have the same general function, paralogues usually differ in specific biochemical details such as the primary target or a required co-factor [ 36].
Indeed, it may improve BCVA and CMT by acting against different biochemical targets involved in the pathogenesis of DME, such as VEGF, IL-8, IL-10, TGF-β, and TNF-α [ 5, 6], even if its effect decreases slightly over time.
