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This little biochemical switch turns out to have potentially devastating health effects.
Here, we present a lipase mutant containing a biochemical switch allowing a controlled opening and closing of the lid independent of the environment.
Its signal-response curve appears sigmoidal, constituting a biochemical switch.
The potential role of Tyr682 phosphorylation state as a "biochemical switch" to change the molecular composition of APP complexes is an intriguing possibility.
We also studied the effect of dynamic disorders on the proposed biochemical switch, in which the enzymatic reaction rates, instead of constant, appear as stochastic functions of time.
Phosphorylation-driven ubiquitination through the SCF pathway and subsequent proteasomal degradation have been considered as a biochemical switch crucial for coordinating phase changes during the cell cycle [6], [7].
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Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis.
The Ferrell lab is working to understand the design principles of biochemical switches, timers, and oscillators, especially those that control the cell cycle.
Since all-or-none decisions of the cell are controlled by extracellular signals, cells have biochemical switches within their intracellular signaling networks.
Biochemical switches are biochemical reaction networks with the capacity for two different stable steady states.
In the previously proposed stochastic models of bistable biochemical switches, cells are able to switch forth and back between the possible qualitative states of the switch.
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