Exact(8)
This is the biochemical demonstration of a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase.
In addition to engineering, this work better defines the macrocyclization mechanism, provides the first biochemical demonstration of Ser/Thr posttranslational prenylation, and is the first example of reconstitution of a native, multistep RiPP pathway with multiple enzymes in one pot.
The biochemical demonstration that AID deaminates C in single stranded (ss) DNA led to the proposal that transcription triggers separation of the DNA strands, each ss DNA is then exposed to the action of AID [6], [14] [17].
Here, we report for the first time a direct biochemical demonstration of pathological prion protein PrPTSE and of PrPTSE-associated seeding activity, the static and dynamic biochemical markers for biological prion infectivity, respectively, in skeletal muscles of CWD-infected cervids, i. e. WTD for which no clinical signs of CWD had been recognized.
Moreover, our biochemical demonstration of Kip2 phosphorylation suggests that additional layers of regulation may exist.
This is the first biochemical demonstration that the methanogen gene MTH0830 encodes RFAP synthase.
Similar(52)
This is a demonstration that biochemical models are amaneable for studies using the concept developed in this paper.
The diagnosis is made on clinical and biochemical features, with the demonstration of an elevated plasma VIP.
Raman spectroscopy is a highly sensitive and specific technique for demonstration of biochemical changes in the carcinogenesis of Barrett's oesophagus.
Upon demonstration by biochemical and biological activity assays that the LBD of LasR receptor proteins can fold into a functional conformation in the absence of its cognate acyl-HSL ligand, SERS spectroscopy allowed us to obtain direct experimental evidence of conformational changes in LasRLBD upon interaction with activators and inhibitors of P. aeruginosa quorum sensing.
The drugs also enabled the demonstration that biochemicals such as neurotransmitters are involved in mental disorders, even if their role turned out to be more complicated than originally thought.
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