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Biochemical analyses will be carried out centrally in an accredited clinical laboratory.
Further biochemical analyses will be needed to establish the mode of action of accessory proteins of the Hsp100/Clp complex.
Biosamples include venous blood, faeces, urine and nail clippings, which, among other biochemical analyses, will be characterised at genetic, transcriptomic, metabolomic, proteomic and metagenomic levels.
It is clear that sequence data alone cannot accurately predict specific three-component signaling pathways in the trypanosomatids – detailed biochemical analyses will be required.
Ultimately, more detailed biochemical analyses will be required to elucidate precisely how VCP functions at lysosome membranes and how this activity might be coordinated with other aspects of VCP function throughout the cell.
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Future detailed biochemical and physiological analyses will be needed to deeply characterize the function of LRS1 in C. reinhardtii.
Targeted biochemical and metabolite analyses will be necessary to validate whether Ferredoxin class gene functions are crucial for chlorosis tolerance.
Biochemical and functional analyses will be required to determine the importance of these predicted enzymes in the ability of the pathogen to survive and flourish in its host.
Biochemical analyses will hence be required to determine the exact physiological function of each amphioxus member of the iLbp family.
Biochemical analyses will always be restricted by the limited repair tissue available in humans and the small biopsy size (250 μg).
A blood sample for standard biochemical analyses (including hemoglobin) will be sent for processing in the centralized laboratory.
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