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Previously, we reported that microneedles significantly increase the transdermal delivery of hydrophilic l-carnitine in comparison to passive diffusion, and enhance substantially the bioavailability of this peptide compared to oral administration.
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This review focuses on currently developed strategies to improve oral bioavailability of these peptide based drugs; evaluating their advantages and limitations in addition to discussing future perspectives on oral peptides delivery.
As VIP is prone to rapid proteolytic degradation in the microenvironment of the lung a proper delivery system is required to increase the half-life and bioavailability of the peptide.
Moreover, azapeptides were shown to be more stable in biological medium compared to native peptides, and for this reason, they have been used to improve the stability and bioavailability of peptide drugs.
Our work presents an effective design strategy for optimizing natural antiviral peptides and opens a new avenue for enhancing the bioavailability of peptide drugs.
Accordingly, it has been under extensive investigation as a possible strategy to improve the oral bioavailability of peptide and protein drugs.
The goal of this review is to compare these two drug delivery approaches from a physico-chemical and a biopharmaceutical standpoint in an attempt to define how nanotechnology-based products can be differentiated from standard oral dosage forms for oral bioavailability of diabetes peptides.
In this study chitosan-dextran-PVP gel (CDP gel) prepared as a novel and suitable gel based drug delivery system intended to increase the bioavailability of therapeutic peptides and proteins such as EGF toward wound tissue.
In this work, we prepared CDP gel as a suitable gel based drug delivery system to increase the bioavailability of therapeutic peptides and proteins such as EGF to wound tissue.
56 Moreover, DPP-4 inhibitors may exploit the favorable actions of GLP-1 on the cardiovascular system by increasing the bioavailability of this hormone and, additionally, may potentially exert cardioprotective effects via non GLP-1 mediated GLP-1 mediatedolving other peptides.
Furthermore, we have developed a method that can be used to assess the bioavailability of this soil organic phosphorus.
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