Sentence examples for bioavailability of this compound from inspiring English sources

The reduced potency of CP-99,994 probably reflects the poor oral bioavailability of this compound, for when the compound was administered i.p., the MED dose of CP-99,994 decreased to 1 mg/kg (see Table 2).

However, previous toxicity studies applied exposure methods with low bioavailability of this compound, and the actual hazard of decaBDE for humans, which are environmentally exposed to decaBDE, may thus be underestimated in current risk assessments.

Taken together these observations indicate: (i) that the bioavailability of this compound depends on intra pulmonary deposition pattern and; (ii) that dissolution is the rate limiting step governing the systemic absorption rate for this lipophilic drug.

21 We administered TRC210258 in the DIO hamster via the intraperitoneal route because of the lower oral bioavailability of this compound in hamsters compared with mice.

The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound.

We were unable to demonstrate clinical or biochemical evidence of efficacy of Curcumin C3 Complex® in AD in this 24-week placebo-controlled trial although preliminary data suggest limited bioavailability of this compound.

Antioxidant supplementation resulted in an increase in SOD levels, confirming the oral bioavailability of the compound in FIV-infected cats.

Cellular efflux transporters, especially P-glycoprotein (P-gp), impel berberine (BBR) out of cells, and therefore reduce bioavailability of the compound.

Unfortunately, the poor in vivo stability and/or bioavailability of the compound did not permit further use in animal models.

The same dose level was tolerated and active even when delivered p.o., thus suggesting an adequate bioavailability of the compound.

This process provides intestinal environment with a high solubilization capacity for poorly water-soluble drug thereby enhancing the bioavailability of the compound.