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Thus, the sulphamoylation of oestrogens having a 2-methoxy function is an important mechanism for enhancing the potency and oral bioavailability of this class of compound.
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The aim of this current paper is to assess the suitability of this HLB-RSM approach to enhance the oral bioavailability of BCS class II compounds using fenofibrate as drug model.
Amorphous solid dispersions (ASDs) have the potential to offer higher apparent solubility and bioavailability of BCS class II drugs.
Amorphous drug formulations have great potential to enhance solubility and thus bioavailability of BCS class II drugs.
This justifies the fact that HLB-RSM approach could be considered as a promising method for the development of efficient and highly stable SEDDS aiming to increase the poor bioavailability of BCS class II molecules.
Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability.
It is important to note that the beneficial effect of this class of drug is strictly related to its well-demonstrated antioxidant activity, which improves NO bioavailability and goes beyond its antihypertensive effect.
The results provided an evidence for the significance of spray dried emulsion as a leading strategy for improving the solubility and enhancing the bioavailability of class II drugs.
Furthermore, CDs enhance oral bioavailability of FDA's Class II compounds (poor aqueous solubility, high permeability) such as the BZD methylcarbamates [ 17].
Furthermore, we have developed a method that can be used to assess the bioavailability of this soil organic phosphorus.
The oral bioavailability of this medication is not affected by food or time of administration.
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